Jian-Xiong Chen Selected Research

Enzymes

3/2024	Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance.
2/2024	p53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice.
2/2023	P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure.
1/2022	TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.
1/2019	Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease.

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Jian-Xiong Chen Research Topics

Disease

17	Fibrosis (Cirrhosis) 05/2024 - 02/2012
11	Heart Failure 05/2024 - 02/2014
10	Hypoxia (Hypoxemia) 03/2024 - 04/2007
7	Cardiomegaly (Heart Hypertrophy) 02/2024 - 01/2019
7	Microvascular Rarefaction 01/2021 - 08/2015
6	Myocardial Ischemia (Ischemic Heart Diseases) 05/2024 - 04/2007
6	Cardiovascular Diseases (Cardiovascular Disease) 10/2023 - 10/2006
5	Obesity 03/2024 - 12/2008
5	Hypertension (High Blood Pressure) 02/2024 - 10/2006
5	Myocardial Infarction 10/2015 - 06/2008
4	Diabetic Cardiomyopathies 10/2023 - 02/2014
4	Inflammation (Inflammations) 01/2023 - 12/2008
4	Hypertrophy 01/2021 - 09/2012
3	Atherosclerosis 01/2021 - 10/2006
3	Body Weight (Weight, Body) 01/2018 - 12/2012
2	Iron Overload 11/2020 - 01/2019
2	Infarction (Infarctions) 10/2015 - 09/2012
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2014 - 09/2012
1	Mitochondrial Diseases (Mitochondrial Disease) 05/2024
1	Insulin Resistance 03/2024
1	Cardiomyopathies (Cardiomyopathy) 10/2023
1	Friedreich Ataxia (Friedreich's Ataxia) 10/2023
1	Hepatocellular Carcinoma (Hepatoma) 01/2023
1	Chronic Renal Insufficiency 01/2022
1	Diabetes Mellitus 01/2021
1	Cardiovascular Abnormalities 01/2021
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	Vascular Remodeling 09/2016
1	Sepsis (Septicemia) 02/2016
1	Reperfusion Injury 09/2012
1	Corneal Neovascularization 07/2004

Drug/Important Bio-Agent (IBA)

19	Sirtuin 3IBA 05/2024 - 01/2013
9	Glucose (Dextrose)FDA LinkGeneric 03/2024 - 08/2015
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 10/2006
6	ApelinIBA 01/2020 - 09/2012
5	IronIBA 05/2024 - 01/2019
5	EnzymesIBA 03/2024 - 01/2019
5	Angiotensin IIIBA 02/2024 - 01/2020
4	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 03/2024 - 09/2016
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2021 - 01/2014
4	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2020 - 04/2007
2	ferrostatin-1IBA 05/2024 - 01/2023
2	Lysine (L-Lysine)FDA Link 02/2024 - 02/2023
2	Arginine (L-Arginine)FDA Link 02/2024 - 02/2023
2	FructoseIBA 02/2024 - 02/2023
2	CholesterolIBA 01/2021 - 03/2016
2	LipidsIBA 01/2018 - 03/2016
2	Mixed Function Oxygenases (Monooxygenases)IBA 01/2017 - 09/2016
2	Angiopoietin-2IBA 02/2012 - 09/2008
1	Proteins (Proteins, Gene)FDA Link 03/2024
1	Phosphofructokinase-1 (Phosphofructokinase 1)IBA 02/2024
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2023
1	AntibodiesIBA 01/2023
1	PhosphofructokinasesIBA 01/2022
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2022
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2020
1	oxidized low density lipoproteinIBA 01/2020
1	ConnectinIBA 10/2019
1	Atrial Natriuretic Factor (ANF)IBA 01/2018
1	oil red OIBA 01/2018
1	SirtuinsIBA 07/2016
1	NAD (NADH)IBA 07/2016
1	Caveolin 1IBA 03/2016
1	AngiotensinsIBA 09/2012
1	CXCR ReceptorsIBA 09/2012
1	LigandsIBA 09/2012
1	apelin-13 peptideIBA 09/2012
1	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2008
1	Streptozocin (Streptozotocin)FDA Link 06/2008
1	AngiopoietinsIBA 06/2008
1	erucylphosphocholineIBA 06/2008
1	Mitogen-Activated Protein KinasesIBA 04/2007
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 04/2007
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 04/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2004

Therapy/Procedure

2	Ligation 07/2016 - 01/2013
1	Liver Transplantation 01/2023
1	Acupuncture Therapy 12/2012